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(2010)show that SIRT3-/- knockout mice show accelerated agingphenotypes, including classical mitochondrial swelling.Although earlier work on OS and CR emphasized the roleof SIRT1 and its homologs (Sinclair, 2005), recent workhas demonstrated that SIRT3 appears essential for CR-mediated reduction in OS (Qiu et al., 2010), as homony-mous knockout of SIRT3 prevents the expected reductionof OS during CR.

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